Nguyễn Thanh Quang2022-11-032022-11-032020https://repository.vlu.edu.vn/handle/123456789/82110.37358/Rev.Chim.1949Magnetic resonance imaging ( is one of best imaging technologies to monitor transplanted stem cells, because of its high anatomical resolution and safety. In this study, we aim to synthesize Poly (styrene sulphonate) coated Gd 3+ Poly (lactide co glycolic acid) Perfluorooctyl Bromide nanoparticles (PSS coated Gd 3+3+@ for stem cell labeling using both 1 H and 19 F MRI. At a weight ratio 20 of PLGA/ Gd 3+ NPs have a spherical shape with the hydrodynamic siz e at 180 nm with zeta potential at 53 mV. In vitro we obtain the intended T1 relaxation acceleration of water on 1 H MRI. The NPs have low toxicity to the human mesenchymal stem cells ( up to 1 mg/ml. They could internalize into the stem cells via ca veolae mediated endocytosis efficiently, confirmed by flow cytometry analysis, and gives a good contrast in both channels 1 H and 18 F MRI scans. In conclusion, our NPs have shown a great potential as a dual contrast agent in MRI for stem cell monitoring.en-USMRI contrast agentgadoliniumperfluoroocctyl bromidestem cell monitoringResource Types::text::journal::journal article