Ho Thi Ngoc Tram2022-10-132022-10-132020https://repository.vlu.edu.vn/handle/123456789/250Catechins from Green tea (Camellia sinensis) is widely known for many biological activities, special anti-cancer and anti-inflammatory properties. Catechins were extracted by mechanical blending, and using citric acid, with 2.31% in extraction efficiency. The result of determining by HPLC-UV showed that Catechin< EC < EGC < ECG < EGCG in concentration compared to dry powder, reaching a total content of 634.51 mg/g, higher than tea powder (537.65 mg/g). Then, anti-inflammatory and anticancer activities of these extracts were investigated. Cell viability assay (MTT) showed that catechin extracts were not toxic to Normal Human Dermal Fibroblasts Cells. They even exhibited anti-inflammatory activities by suppressing the production of NO and proinflammatory cytokines. The results also showed that the extracted catechin powder also showed good anti-inflammatory activity, at a concentration of 45 ?g/mL, NO proliferation reached 44.4%. Anticancer activities of these extracts were displayed through their ability to inhibit the growth of cancer cell lines: liver cancer cell line (HepG2), lung cancer cell line (A549), leukemia cancer cell line (K562), with IC50 values of 181.1 μg/mL, 186 μg/mL, 137.8 μg/mL, respectively. So catechin extracts from green tea may have the potential to be applied in pharmaceutical.en-USGreen tea extractCamellia sinensiscatechinsanti-inflammatoryanticancerHepG2A549K562Resource Types::text::journal::journal article